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M94A2915.TXT
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1994-10-25
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Document 2915
DOCN M94A2915
TI HIV and the brain: P300 changes do not reflect general subcortical
damage.
DT 9412
AU Katner HP; Moore NC; Tucker KA; Smith MU; Coburn KL; Department of
Medicine, Mercer University School of Medicine,; Macon, GA 31208.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):196 (abstract no. PB0214). Unique
Identifier : AIDSLINE ICA10/94369660
AB OBJECTIVES: Evidence of HIV encephalopathy can be found shortly after
seroconversion as a delayed and attenuated P300 auditory event related
potential (ERP) component. P300 changes occur before dementia, while the
EEG is normal, and increase with successive infection stages (Coburn et
al. NeuroReport 3(6): 539-541, 1992). This could reflect either a
general subcortical deterioration or a more specific involvement of the
hippocampal pathways mediating the P300 and other cognitive functions. A
general subcortical deterioration should involve the widely distributed
subcortical visual pathways, producing visual ERP abnormalities.
METHODS: Pattern reversal ERP's (N75, P100 & asymptomatic HIV+ (n = 10),
ARC (n = 9), and AIDS (n = 9) subjects. RESULTS: Although these HIV
patients had highly significant P300 changes, visual ERP's did not
differ between any patient group and healthy controls, or between
patient groups representing increasing infection stages. DISCUSSIONS &
CONCLUSIONS: The finding of normal visual ERP's with progressive P300
changes suggests that the earliest subcortical involvement is of the
hippocampal circuitry rather than being diffuse.
DE *Evoked Potentials, Auditory Evoked Potentials, Visual
Hippocampus/*PHYSIOPATHOLOGY Human HIV Infections/*PHYSIOPATHOLOGY
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).